Article views are the countercompliant sum of full text article downloads since november 2008 both pdf and html across all institutions and individuals. Recent advances in cns research and drug discovery are presented, especially with regard to assessment of relevant neuropk parameters. Expert collection 2019 title list 2019 print issn online. Download the list of journals included in this collection. How do we improve histone deacetylase inhibitor drug.
Pdf drug repurposing approaches to fight dengue virus. The flow cytometer is unique among biomedical analysis instruments because it makes simultaneous and multiple optical measurements on individual cells or particles at. It can be used to estimate the molecular activity of drugs and to establish a drug s physicochemical properties such as its partition coefficient. Pdf maximizing computational tools for successful drug discovery. Docking screens for dual inhibitors of disparate drug.
Browse the list of issues and latest articles from expert opinion on drug discovery. Discovery and development of varenicline for smoking. The drug maker manipulated the publication of studies to bolster use of its epilepsy drug neurontin, according to expert witnesses in a lawsuit against the company. Broadspectrum coronavirus antiviral drug discovery. Expert opinion fluoxetine is the first selective ssri that has a recognised clinical efficacy and safety profile. Users can view or download content wherever they are. Journals are listed alphabetically by journal name, and also grouped by the subfield of medicine they focus on. Expert opinion instructions for authors submitting to the expert collection. It was originally called microbia, inc microbia was founded by postdocs from the lab of gerald fink at the whitehead institute to commercialize approaches that had been developed in the lab to improve industrial fermentation of fungi, to genetically engineer them to produce secondary metabolites more efficiently or to. All journal articles featured in expert opinion on drug discovery vol issue 1. Medical journals are published regularly to communicate new research to clinicians, medical scientists, and other healthcare workers. Recent studies suggest that substances that modulate glutamatergic system may produce an antidepressant. Computational prediction of oral drug absorption based on. Iebt expert opinion on biological therapy 14712598 17447682 20.
All journal articles featured in expert opinion on drug discovery vol 15 issue 5. After years of industrywide disinvestment from antibiotic research, a few large companies are reinvesting. Expert opinion on drug discovery 2016 optimizing celgosivir therapy in mouse models of dengue virus infection of serotypes 1 and 2. Mechanistic models enable the rational use of in vitro. Including address, academic qualifications and job titles of all authors, as well as telephone number and email address of the author for correspondence on a. Since its discovery, other molecules that mimic its mechanism of action have been developed, commencing a new age in the treatment of depression. Pages in category pharmacology journal stubs the following 72 pages are in this category, out of 72 total. While the oral route of delivering a drug remains the most convenient and common mode, one of the challenges of this method is the poor bioavailability of oral dosage. Expert opinion on drug discovery 2010 download pdf. Expert opinion on drug discovery 2015, 10 4, 345371. Influential journals include expert opinion on biological therapy, expert opinion on drug delivery, expert opinion on investigational drugs, and expert opinion on therapeutic targets. If you have problems viewing pdf files, download the latest version of adobe reader.
The editorinchief david janero northeastern university abstracting and indexing. Article pdf available in expert opinion on drug discovery 56. Ironwood pharmaceuticals, inc is a publicly traded pharmaceutical company. Further work is required to expand the number of enzymes that could be exploited to direct. Pdf expert opinion on drug discovery glutamatebased. It can also be used in compatibility studies during the drug formulation process. These metrics are regularly updated to reflect usage leading up to the last few days. The rationale for creating a 3rd mechanism for drug discovery which works linking biopharma with fundamental research is thoroughly compelling. Pages in category pharmacology journals the following 161 pages are in this category, out of 161 total. Deuterated drugs collectively are worth at least a billion dollars. It would seem that the likelihood of obviousness rejections is increasing in this area.
Accelerating drug discovery through tight integration of. Raman spectroscopy has a number of potential applications within drug discovery and development. Volume 15 2020 volume 14 2019 volume 2018 volume 12 2017 volume 11 2016 volume 10 2015 volume 9 2014 volume 8 20 volume 7 2012 volume 6 2011 volume 5. Expert opinion on drug discovery 2016, 11 10, 10011016. There have been a number of highthroughput assays developed in recent years to meet the scaled up demands for compound profiling. This article lists academic journals that focus on the practice of medicine or any medical specialty.
Based on lessons learned from sars and mers outbreaks, lack of drugs. National center for advancing translational sciences. Expert opinion on drug discovery rg journal impact. Classic antidepressants that modulate monoaminergic systems are not sufficiently effective and require long systematic application. Development of nobased therapeutics is and will continue to be a major focus of biotech and. Explore archive content from our portfolio of expert opinions in our modern archive package. The poor solubility of a compound can lead to reduced productivity in terms of drug discovery and development. Induced degradation by stateoftheart compounds proteolysistargeting chimeras, protacs has been shown for protein kinases, albeit in early preclinical stages. Expert opinion on drug discovery 2019 promiscuity of in vitro secondary pharmacology assays and implications for lead optimization strategies dean g. Expert opinion on drug discovery 2019 download pdf. The role of lipophilicity in determining the overall quality of candidate drug molecules is of paramount importance. Learning from structurebased drug design and new antivirals targeting the ribonucleoprotein complex for the treatment of influenza. Treatment of sars and mers in outbreak settings has focused on therapeutics with general antiviral activity and good safety profiles rather than efficacy data provided by cellular, rodent, or nonhuman primate models of highly pathogenic coronavirus infection. Download hires image download to mspowerpoint cite this.
How do we improve histone deacetylase inhibitor drug discovery. Suggestions for further improvements are also discussed. You can also order 1 set of 100 at a discounted rate of. Molecular mechanisms underlying chemical liver injury. Expert opinion on drug metabolism and toxicology 4, 545568. Drug discovery today the magazine for the drug discovery. Drug discovery efforts are now involved with finding compounds that may affect known signaling pathways involved in hair growth, hf cycling and stem cell mobilization, differentiation and proliferation. Acronym title print issn online issn 2019 volume number url iebt expert opinion on biological therapy 14712598 17447682 19.
Accelerating drug discovery through tight integration of expert molecular design and predictive scoring. Discovery and development of varenicline for smoking cessation. Recent developments suggest that, as well as determining preclinical admet absorption, distribution, metabolism, elimination and toxicology properties, compounds of optimal lipophilicity might have increased chances of success in. Expert opinion 2020 print issn online issn volume url. Expert opinion on drug discovery offprints and colour figure order form you are entitled to 10 free offprints of your paper not for distribution to information companies.
The search for a window for potential therapeutic efficacy. Structural information on gpcrs will be more abundantly available for early stages of drug discovery projects, providing. The journal is abstracted and indexed in chemical abstracts, embaseexcerpta medica, and science citation index expanded. Investigation of the relationship between topology and. Expert opinion on drug discovery abbreviation issn. Pdf drug discovery is an iterative cycle of identifying promising hits followed by lead optimization via bioisosteric replacements. However, careful elucidation of metabolic outcomes from deuteration that would not be anticipated from the prior art, and are instead unexpected and unobvious, has enabled. Expert opinion with the recent progress in biophysical detection techniques the advantages of fragmentbased drug discovery could be exploited for gpcr targets. Expert opinion on drug discovery 2019, 14 7, 619637. Recent developments suggest that, as well as determining preclinical admet absorption, distribution, metabolism, elimination and toxicology properties, compounds of optimal lipophilicity might have increased chances of success in development.
All article types should have a concise, informative title that contains no brand names. Pdf application of nitric oxide in drug discovery and development. Mechanism of action of cariprazine volume 21 issue 2 stephen m. Importance of solubility and lipophilicity in drug development. Discovery of a novel, firstinclass, orally bioavailable. Expert opinion on drug discovery offprints and colour. Molecular mechanisms underlying chemical liver injury volume 14 xinsheng gu, jose e.
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